Peroxisomal Bifunctional Enzyme

A monomeric protein found in liver peroxisomes that contains two enzymatically active domains; an enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase domain, and an (S)-3-hydroxyacyl-CoA dehydrogenase domain. The enzyme is stereospecific with regards to how cis and trans double bonds are metabolized. It is complemented by PEROXISOMAL MULTIFUNCTIONAL PROTEIN-2, which has the opposite stereospecificity.

Also Known As:

2-Enoyl-CoA Hydratase, 3-Hydroxyacyl-CoA Dehydrogenase-delta 3, delta 2-Enoyl-CoA Isomerase; Enoyl-CoA Hydratase-3-Hydroxyacyl-CoA Dehydrogenase; L-Bifunctional Enzyme; L-Peroxisomal Bifunctional Enzyme; Peroxisomal Hydratase-Dehydrogenase-Epimerase; Peroxisomal Multifunctional beta-Oxidation Protein; Peroxisomal Trifunctional Enzyme; Bifunctional Enzyme, L-Peroxisomal; Bifunctional Enzyme, Peroxisomal; Dehydrogenase, Enoyl-CoA Hydratase-3-Hydroxyacyl-CoA; Enoyl CoA Hydratase 3 Hydroxyacyl CoA Dehydrogenase; Hydratase-3-Hydroxyacyl-CoA Dehydrogenase, Enoyl-CoA; Hydratase-Dehydrogenase-Epimerase, Peroxisomal; L Bifunctional Enzyme; L Peroxisomal Bifunctional Enzyme; Peroxisomal Bifunctional Enzymes; Peroxisomal Hydratase Dehydrogenase Epimerase; Peroxisomal Multifunctional beta Oxidation Protein; Peroxisomal-Bifunctional Enzymes

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
        3-Hydroxyacyl CoA Dehydrogenases
        3-Hydroxyacyl-CoA Dehydrogenase: 130
        Peroxisomal Bifunctional Enzyme: 18
  - Lyases: 637
    - Carbon-Oxygen Lyases
      - Hydro-Lyases: 266
        Enoyl-CoA Hydratase: 61
        Peroxisomal Bifunctional Enzyme: 18
  - Isomerases: 463
    - Intramolecular Oxidoreductases
      - Carbon-Carbon Double Bond Isomerases
        Dodecenoyl-CoA Isomerase: 2
        Peroxisomal Bifunctional Enzyme: 18
  - Multifunctional Enzymes: 108
    - Peroxisomal Bifunctional Enzyme: 18

Fred L DeRoos Selected Research

Fred L DeRoos Research Topics

Disease

Drug/Important Bio-Agent (IBA)